gastrin

Gastrin is a peptide hormone produced primarily by G cells located in the stomach lining, especially the antrum region, and to a lesser extent in the small intestine. Its main function is to stimulate the stomach to produce gastric acid (hydrochloric acid), which helps digest food and activate digestive enzymes. Gastrin also supports normal growth and function of the stomach lining. Gastrin release is normally controlled by food intake and stomach acidity. Excessive gastrin production, such as from gastrin-secreting tumors called gastrinomas, can cause very high acid levels and contribute to Zollinger-Ellison syndrome and recurrent peptic ulcers.

Gastrin is a hormone that tells the stomach to make acid needed for digestion. Too much gastrin can cause excessive stomach acid and lead to problems such as ulcers.

• Digestive hormone produced mainly by the stomach • Secreted by specialized cells called G cells • Stimulates production of gastric acid (hydrochloric acid) • Helps digestion and supports stomach function • Levels normally change depending on food intake and stomach acidity • Excess gastrin may occur with gastrinoma and Zollinger-Ellison syndrome