antilymphocyte serum

Antilymphocyte serum (ALS), also known as antilymphocyte globulin (ALG) or antithymocyte globulin (ATG), is a biologic immunosuppressive agent containing antibodies directed against human T lymphocytes. It is produced by immunizing animals such as horses or rabbits with human lymphoid cells and then purifying the resulting antibodies. These antibodies bind to lymphocytes, particularly T cells, leading to their destruction or functional suppression. ALS/ALG/ATG is widely used in organ transplantation to prevent or treat acute rejection and in the management of certain autoimmune diseases and aplastic anemia. Because it suppresses immune function, treatment may increase the risk of infections, infusion reactions, and certain malignancies. Administration is typically by intravenous infusion under close medical supervision.

Antilymphocyte serum (ALS) is a medicine that weakens the immune system by reducing the number and activity of certain white blood cells called lymphocytes. Doctors commonly use it to help prevent the body from rejecting a transplanted organ or to treat some serious immune system disorders.

• Also known as antilymphocyte globulin (ALG) or antithymocyte globulin (ATG) • Immunosuppressive biologic preparation containing antibodies against lymphocytes • Primarily targets T lymphocytes, reducing immune system activity • Commonly used in organ transplantation to prevent or treat transplant rejection • Also used in conditions such as aplastic anemia and certain autoimmune disorders • Usually produced from horse- or rabbit-derived antibodies • Administered by intravenous infusion under medical supervision • May cause infusion reactions, fever, chills, and increased risk of infections • Long-term immunosuppression may increase the risk of certain cancers and opportunistic infections