adrenocorticotrophic hormone

Adrenocorticotrophic hormone (ACTH), also known as corticotropin, is a peptide hormone produced and secreted by the anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from the hypothalamus. ACTH plays a key role in the hypothalamic-pituitary-adrenal (HPA) axis by stimulating the adrenal cortex to produce and release corticosteroid hormones, particularly cortisol, which helps regulate metabolism, stress response, immune function, and inflammation. Abnormal ACTH levels may occur in conditions such as Cushing disease, adrenal insufficiency, and pituitary disorders. Synthetic ACTH may also be used diagnostically to evaluate adrenal gland function and therapeutically in certain inflammatory, autoimmune, or neurological conditions.

Adrenocorticotrophic hormone (ACTH) is a hormone made by the pituitary gland in the brain that tells the adrenal glands to produce important stress-related hormones like cortisol. These hormones help the body respond to stress, control inflammation, and regulate energy use.

• Also called corticotropin or ACTH • Hormone produced by the anterior pituitary gland • Stimulates the adrenal glands to release corticosteroid hormones, especially cortisol • Important part of the body’s stress-response system (HPA axis) • Helps regulate metabolism, immune function, inflammation, and stress response • ACTH testing may be used to evaluate adrenal or pituitary gland disorders • Synthetic ACTH can be used in diagnostic testing and certain medical treatments