nephroblastoma
Nephroblastoma, also known as WILMS TUMOR, is a malignant KIDNEY CANCER that develops from immature KIDNEY CELLS and primarily affects children, especially during early childhood.
Nephroblastoma (WILMS TUMOR) is an EMBRYONAL TUMOR of the KIDNEY that arises from abnormal development of primitive METANEPHRIC BLASTEMA cells during KIDNEY DEVELOPMENT. It is the most common type of RENAL CANCER in children and typically presents as an abdominal mass. Nephroblastoma may be associated with GENETIC MUTATIONS affecting genes such as the WT1 GENE and can occur as part of congenital syndromes including WAGR SYNDROME, DENYS-DRASH SYNDROME, and BECKWITH-WIEDEMANN SYNDROME. Diagnosis involves ULTRASOUND, COMPUTED TOMOGRAPHY (CT), and histological examination, while treatment commonly includes SURGERY, CHEMOTHERAPY, and sometimes RADIATION THERAPY.
Nephroblastoma, also called Wilms tumor, is a type of kidney cancer that mostly affects young children.
• It develops from immature kidney cells that fail to grow normally. • It is the most common kidney cancer in children. • A common sign is a painless swelling or lump in the abdomen. • Some cases are linked to changes in genes involved in kidney development. • Diagnosis usually involves imaging tests and examination of tumor tissue. • Treatment often includes surgery, chemotherapy, and sometimes radiation therapy. • With early diagnosis and proper treatment, many children have a good outcome.
Wilms tumor is a rare type of kidney cancer. It causes a tumor on one or both kidneys. It usually affects children, but can happen in adults. Having certain genetic conditions or birth defects can increase the risk of getting it. Children that are at risk should be screened for Wilms tumor every three months until they turn eight.
Symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. Tests that examine the kidney and blood are used to find the tumor.
Doctors usually diagnose and remove the tumor in surgery. Other treatments include chemotherapy and radiation and biologic therapies. Biologic therapy boosts your body's own ability to fight cancer.
NIH: National Cancer Institute
nephroblastoma