Multiple Endocrine Neoplasia Type 1

Multiple endocrine neoplasia type 1 (MEN1), also known as Wermer syndrome, is a hereditary condition caused by changes in the MEN1 gene. It increases the likelihood of developing tumors in several endocrine organs, most commonly the parathyroid glands, pancreas, and pituitary gland. These tumors may produce excessive hormones and cause symptoms related to hormone imbalance. Common manifestations include primary hyperparathyroidism, pancreatic neuroendocrine tumors such as gastrinomas or insulinomas, and pituitary tumors. MEN1 is usually inherited in an autosomal dominant pattern, meaning a genetic change can be passed from parent to child. Management involves regular screening, monitoring, and treatment of specific endocrine tumors.

MEN1 is a rare inherited condition that makes a person more likely to develop tumors in hormone-producing glands such as the parathyroid, pancreas, and pituitary gland.

• Rare inherited endocrine tumor syndrome • Caused by changes in the MEN1 gene • Also called Wermer syndrome • Increases risk of tumors in multiple endocrine glands • Commonly affects parathyroid glands, pancreas, and pituitary gland • Associated with pancreatic neuroendocrine tumors including gastrinomas • Can cause excessive hormone production • Requires long-term medical monitoring and management