gastrinoma

A gastrinoma is a type of neuroendocrine tumor that secretes abnormally high levels of gastrin. Excess gastrin stimulates the stomach to produce large amounts of gastric acid, leading to Zollinger-Ellison syndrome, recurrent peptic ulcers, gastroesophageal reflux symptoms, and diarrhea. Gastrinomas most commonly develop in the duodenum or pancreas. They may occur as isolated tumors or as part of multiple endocrine neoplasia type 1 (MEN1), a hereditary endocrine tumor syndrome. Some gastrinomas grow slowly, while others may become malignant and spread to other organs. Diagnosis involves measuring gastrin levels, acid secretion, imaging studies, and tumor localization.

A gastrinoma is a rare tumor that makes too much gastrin hormone. This causes the stomach to produce too much acid, which can lead to repeated ulcers and digestive problems.

• Rare hormone-producing neuroendocrine tumor • Produces excessive gastrin hormone • Causes increased stomach acid production • Main cause of Zollinger-Ellison syndrome • Often occurs in the duodenum or pancreas • May cause ulcers, reflux symptoms, abdominal pain, and diarrhea • Can occur with multiple endocrine neoplasia type 1 (MEN1) • Some gastrinomas may be malignant