alteplase

a TISSUE-TYPE PLASMINOGEN ACTIVATOR made by recombinant DNA technology (genetic engineering). Alteplase is used to dissolve blood clots ( see FIBRINOLYTIC ), especially in the coronary arteries of the heart. It is administered by injection. Possible side-effects include local bleeding, cerebral haemorrhage, nausea, and vomiting. Trade name: Actilyse.